Horse Chestnut

Common name

buckeye, Spanish chestnut,Horse-Chestnut Seed,Horse-chestnut bark

ID

HD0174

Scientific name of the plant

Aesculus hippocastanum L.

Anatomical part for use

seed, bark, leaf

Human use

Urinary tract and genital disorders,Circulatory disorders

Summary

The genus Aesculus ( or ), with varieties called buckeye and horse chestnut, comprises 13–19 species of flowering plants in the family Sapindaceae. They are trees and shrubs native to the temperate Northern Hemisphere, with six species native to North America and seven to thirteen species native to Eurasia. Several hybrids occur. Aesculus exhibits a classical Arcto-Tertiary distribution.Mexican buckeye seedpods resemble the Aesculus seedpods, but belong to a different genus. Carl Linnaeus named the genus Aesculus after the Roman name for an edible acorn. Common names for these trees include "buckeye" and "horse chestnut", though they are not in the same order as chestnut trees. Some are also called white chestnut or red chestnut. In Britain, they are sometimes called conker trees because of their link with the game of conkers, played with the seeds, also called conkers. (Source: Wiki)

Evidence Level

Level 2 (Independent reports from multiple medical centers)

Hepatotoxicity reports in literature

  • A case of Venoplant-induced hepatic injury : (Source)
  • Hepatotoxicity associated with herbal tablets : (Source)

Hepatotoxicity Description

Despite wide scale use, there have been few published instances of liver injury due to horse chestnut. In isolated cases of liver toxicity attributed to horse chestnut extracts, injury became apparent between 4 and 8 weeks after starting the herbal and were associated with either hepatocellular or mixed patterns of serum enzyme elevations and with a self-limited, rapidly resolving course. Immunoallergic and autoimmune features were not present or not mentioned. (Source: LiverTox)